Which of the following allosterically activates mammalian isocitrate dehydrogenase?a. ADPb. NADHc. ATPd. MalateCitrate
1 answer:
Answer:
a. ADP
Explanation:
Isocitrate dehydrogenase is an enzyme in citric acid cycle that occurs in mitochondrial matrix.
It catalyzes conversion of the isocitrate to the alpha-ketoglutarate and Carbon dioxide which occurs in a two step process.
<u>IDH is regulated allosterically by the ADP positively in the mammals and inhibited by ATP, NADH.</u>
The enzyme, IDH will not catalyze the reaction unless there are low levels of ADP.
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P x V = n x R x T
P x 73 = 2.97 x 0.082 x 298
P x 73 = 72.57492
P = 72.57492 / 73
P = 1.0 atm
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