2 years ago

Which of the following allosterically activates mammalian isocitrate dehydrogenase?a. ADPb. NADHc. ATPd. MalateCitrate

Chemistry

1 answer:

Bogdan [553]2 years ago

5 0

Answer:

a. ADP

Explanation:

Isocitrate dehydrogenase is an enzyme in citric acid cycle that occurs in mitochondrial matrix.

It catalyzes conversion of the isocitrate to the alpha-ketoglutarate and Carbon dioxide which occurs in a two step process.

<u>IDH is regulated allosterically by the ADP positively in the mammals and inhibited by ATP, NADH.</u>

The enzyme, IDH will not catalyze the reaction unless there are low levels of ADP.

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