School, work, Lifestyle, The amount of problems a person can take, Relationships, ect.
OK so basically the best thing Karen can do is to keep her diet balanced and exercise regularly to keep an appropriate bmi.
The answer to your problem is c
Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder.
