Question

Write a chemical equation for the acid-base reaction that occurs when p-phenetidine is dissolved in hcl. why is

Answer 1

Answer;

EtO-PHE-NH2 + H+ _______ EtO-PHE-NH3+ Cl-

Explanation;

• p-phenetidine is p-ethoxy aniline so the amino group acts as a base. The free electron pair on nitrogen will form a coordinate covalent bond with the H+ from the ionized HCl.
• HCl is used for the acid-base reaction in p-phenetidine in amide synthesis of acetophenetidin rather than water becuase HCl's polarity contributes to a reaction driven to the right. It protonates the amine group, making it easy to dissolve.