Answer: c. proteasome
Explanation:
Proteasomes are extremely important multi-catalytic proteases and are involved in various cellular functions. The proteasome is an essential component of eukaryotic cells and is responsible for the ATP-dependent proteolytic degradation of most cellular proteins. They are present in the nucleus and cytosol and can represent up to 1% of total cell proteins. Proteasomes generally degrade proteins to small peptides, most of which are rapidly hydrolyzed by cytoplasmic exopeptidases. It catalyzes the rapid degradation of many enzymes, regulatory proteins, and eliminates abnormal proteins resulting from mutation or damaged proteins. The inability of this cellular organelle can lead to neurodegenerative diseases, such as Parkinson´s disease.
Answer:
A. Prions do not contain genetic information, which is affected by ionizing radiation.
B. Denaturants may affect the tertiary structure of prions.
C. Prions are proteins.
Explanation:
Prions are the proteinaceous infectious particles that cause many degenerative diseases of neurons in both animals and humans. They consist of only protein and no DNA or RNA. Due to the absence of DNA or RNA as genetic material, these infectious particles are resistant to ionizing radiation. Ionizing radiations affect nucleic acids of pathogens to destroy them.
Denaturation of proteins affects their secondary and tertiary structures and leave them non-functional. Denaturation may be caused by changes in temperature, pH, disturbance of hydrogen bonds, etc. Therefore, to destroy prions, they need to be denatured.
