Question

At normal blood pH pH (7.4), hemoglobin is 80 80 % saturated at a partial pressure of oxygen ( O 2 O2 ) of 40 mmHg 40 mmHg . Use the oxygen–hemoglobin dissociation curves to determine the oxygen saturation of hemoglobin at a partial pressure of O 2 O2 of 40 mmHg 40 mmHg , if the blood pH pH drops to 7.2.

Answer 1

Answer:

An example of oxygen–hemoglobin (O2–Hb) dissociation curves from (A) one penguin at pH 7.5, 7.4 and 7.3, and (B) the emperor penguin, the bar-headed goose (Anser indicus) (Black and Tenney, 1980) and the domestic duck (Anas platyrhynchos, forma domestica) (Hudson and Jones, 1986) at pH 7.4. Note that as for the bar-headed goose, the O2–Hb dissociation curve of the emperor penguin is significantly left-shifted as compared with the domestic duck (and most birds). The bar-headed goose photo is courtesy of Graham Scott; the domestic duck photo is by Maren Winter (licensed under the terms of the GNU Free Documentation License, Version 1.2 or any later version); the penguin photo is by J.M.

Explanation:

The resulting regression equations from the plots of log[SO2/(100–SO2)] vs log(PO2) (all saturation points, all penguins combined) were:

pH 7.5: log[SO2/(100–SO2)] = 2.92589 × log(PO2) – 4.24338 (N=43, r2=0.98, P<0.0001),

pH 7.4: log[SO2/(100–SO2)] = 2.94767 × log(PO2) – 4.39858 (N=70, r2=0.98, P<0.0001),

pH 7.3: log[SO2/(100–SO2)] = 3.04945 × log(PO2) – 4.72019 (N=38, r2=0.99, P<0.0001),

pH 7.2: log[SO2/(100–SO2)] = 3.15958 × log(PO2) – 4.97618 (N=9, r2=0.99, P<0.0001).