Which of the following is the requirement for the intramolecular Sn2 reaction (intramolecular William Ether Synthesis) to occur
in your reaction? Group of answer choices Anti-periplanar The arrangement of the bromine and hydroxide does not matter. cis Z
1 answer:
Answer:
D. Anti-periplanar
Explanation:
In the <u>second step</u> of the intramolecular William Ether Synthesis mechanism (figure 1) we will have the attack of the negative charge of the oxygen to the carbon bond to the Br. At the same time the Br leaves, so a bond would be broken (the <u>C-Br</u> bond) and a bond would be formed (the <u>C-O</u> bond).
Now, this process can happen only if the <u>attack</u> and the <u>leaving group </u>has an anti configuration (figure 2). In an anti configuration the <u>nucleophile</u> and the <u>leaving group</u> would have <u>opposite directions</u>.
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Answer:
a. True
b. True
c. False
d. True
Explanation:
a). A a very low substrate concentration , . Thus according to the Machaelis-Menten equation becomes
Here since the varies directly to the substrate concentration [S], the initial velocity is lower than the maximal velocity. Thus option (a) is true.
b). The Michaelis -Menten kinetics equation states that :
Here the initial velocity changes directly with the substrate concentration as is directly proportional to [S]. But
is same for any particular concentration of the enzymes. Thus, option (b) is true.
c). As the substrate concentration increases, the initial velocity also increases. Thus option (c) is false.
d). Option (d) explains the procedures to estimate the initial velocity which is correct. Thus, option (d) is true.