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Salsk061 [2.6K]
3 years ago
10

Amantadine is effective in preventing infections caused by the influenza A virus and in treating established illnesses. It is th

ought to block a late stage in the assembly of the virus. Amantadine is synthesized by treating 1-bromoadamantane with acetonitrile in sulfuric acid to give N-adamantylacetamide, which is then converted to amantadine.
(a) Propose a mechanism for the transformation in Step 1.
(b) Describe experimental conditions to bring about Step 2.

Chemistry
1 answer:
Sliva [168]3 years ago
7 0

Answer:

See image attached

Explanation:

a)

The full reaction mechanism of step 1 was obtained from Bartleby and attached to this answer. The steps involved in the reaction are:

1) Loss of Br- and formation of a carbocation

2) Attack of CH3CN on the carbocation

4) Formation of a quaternary nitrogen intermediate

5) Attack of water on the quaternary nitrogen intermediate

6) Loss of the water molecule

5) Formation of the amide product

b)

i) sodium hydroxide

ii) HCl

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The solubility of water in diethyl ether has been reported to be 1.468 % by mass.' Assuming that 23.0 mL of diethyl ether were a
melomori [17]

Explanation:

As it is given that solubility of water in diethyl ether is 1.468 %. This means that in 100 ml saturated solution water present is 1.468 ml.

Hence, amount of diethyl ether present will be calculated as follows.

                          (100ml - 1.468 ml)

                        = 98.532 ml

So, it means that 98.532 ml of diethyl ether can dissolve 1.468 ml of water.

Hence, 23 ml of diethyl ether can dissolve the amount of water will be calculated as follows.

          Amount of water = \frac{1.468 ml \times 23 ml}{98.532 ml}

                                       = 0.3427 ml

Now, when magnesium dissolves in water then the reaction will be as follows.

                Mg + H_{2}O \rightarrow Mg(OH)_{2}

Molar mass of Mg = 24.305 g

Molar mass of H_{2}O = 18 g

Therefore, amount of magnesium present in 0.3427 ml of water is calculated as follows.

           Amount of Mg = \frac{24.305 g \times 0.3427 ml}{18 g}  

                                    = 0.462 g

   

6 0
3 years ago
You mix 145 grams of water with 200 grams of ethanol to make a solution. What is the solute and what is the solvent?
hodyreva [135]

The greater amount is the solvent and the lesser amount is the solute.

Hence ethanol(200g) which is the greater amount is the solvent here.

And water (145g) which is lesser is the solute here.

7 0
3 years ago
How many grams of NH3 can be dissolved in 50 grams of water at 50oC?
weqwewe [10]

15 grams of  NH3 can be dissolved

<h3>Further explanation</h3>

Given

50 grams of water at 50°C

Required

mass of NH3

Solution

Solubility is the maximum amount of a substance that can dissolve in some solvents. Factors that affect solubility  

  • 1. Temperature:
  • 2. Surface area:
  • 3. Solvent type:
  • 4. Stirring process:

We can use solubility chart (attached) to determine the solubility of NH3 at 50°C

From the graph, we can see that the solubility of NH3 in 100 g of water at 50 C is 30 g

So that the solubility in 50 grams of water is:

= 50/100 x 30

= 15 grams

5 0
3 years ago
Which of the following most accurately describes a regulatory molecule that must be transported to its place of action within th
Sonbull [250]

Answer:

the answer is hormone

Explanation:

because it is

5 0
2 years ago
What relationship exists between the mass number of an element and the isotopes of that element?
labwork [276]
The mass number plays an important role for elements and their isotopes. Mass number comes from the addition of protons and neutrons (their weight). Isotopes are the elements, but with a different number of neutrons. So in turn, by subtracting the number of protons (atomic number) from the mass, you can find the number of neutrons.
8 0
3 years ago
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