<span>Peripherally administered (outside of the central nervous system) dopamine is not effective because it cannot cross the blood brain barrier.4 The reason for its inability to cross the blood brain barrier has to do with at least two influencing factors. The first is that dopamine is a hydrophilic molecule that has a greater degree of difficulty in crossing cell membranes. The second is the absence of a transporter for dopamine to get past the blood brain barrier and into the brain.6 Since the increase in dopamine concentrations are needed in the brain and the peripheral administration of dopamine cannot get into the brain, it does not work in the management of symptoms seen in Parkinson's disease. However, the precursor to dopamine, L-dopa, is able to get into the brain via a sodium-independent transport system called, large neutral amino acid carrier system or L (leucine) system.7 Once L-dopa gets inside the brain it can then be metabolized by dopa decarboxylase or amino acid decarboxylase to form dopamine within the dopaminergic neurons within the substantia nigra.4 Therefore, L-dopa versus peripherally administered dopamine is currently the main medication used in the management of symptoms associated with Parkinson's disease.</span>
Spitting lol
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The depressed person may lash out at friends, family members, or medical staff is true depression stage of Kübler-Ross's 5-Stage model and is denoted as option 4.
<h3>What is Kübler-Ross's 5-Stage model?</h3>
These are the stages individuals undergo when dealing with the loss of a loved one.
The five stages include:
- Denial
- Anger
- Bargaining
- Depression
- Acceptance
The depressed person lashing out at friends, family members, or medical staff is a sign of depression.
Read more about Depression here brainly.com/question/21711771
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Before pregnancy...so u wont have birth defects
When it comes to safe patient handling, what it takes to perform this task ergonomically is commitment. This is a very essential training given to those who are handling patients in order to avoid musculoskeletal injuries and damages
it is also correct posture helps.