Question

How many atp equivalents are consumed in the conversion of each of the following to a glucosyl residue in glycogen?

Answer 1

Answer;

Dihydroxyacetone phosphate - 1

Fructose-1,6-bisphosphate - 1

Pyruvate - 13

G-6-P - 1

Explanation;

1) Dihydroxyacetone phosphate = 1

G1P + GTP --> UDPG + PPi two P is equivalent to 2 ATP --->2 ADP + Pi) Therefore, two ATP equivalents - but UDP is the product and only one P needed

2 DHAP --> F1,6-BP -->F6P --> G6P -->G1P -->UDPG --> glucosyl residue

2) Fructose 1,6-bisphosphate = 1

3) Pyruvate = 13

2 pyr + 2 ATP --> 2 OAA

2 OAA + 2 GTP --> 2 PEP

2 PEP --> 2 2PG --> 2 3PG

2 3PG + 2 ATP --> 2 1,3 BPG

2 1,3 BPG + 2 NADH --> 2 G3P

2 NADH = 6 ATP

2 G3P --> DHP + G3P --> FDP -- > F6P + P

F6P --> G6P --> G1P

G1P + UTP --> UDPG + PP

4) Glucose-6-phosphate = 1

G6P -->G1P G1P + UTP --> UDP-GLC + 2 Pi

UDP-Glc + glycogen --> glycogen+ 1 Glc