Question

Can i wash my hands with soap while wearing sterling silver

Answer 1

Yes it should be effective but can cause a rash so safer to take off

Answer 2

Washing your hands using soap with the ring on should not be a problem. 

but rings can slip off during the washing of your hands if it is not an exact fit and soap can build up under the ring and cause a rash on your finger 

If you value the ring, taking it off when washing your hands would be safer