The answer for the question is; during the first trimester. This is because taking recommended dosage of folate starting at least one month before conception and during the first trimester of pregnancy reduce the baby's risk of neural tube defects by up to 70%.
Answer: Biological Mutations
Explanation: Through mutation and selection, bacteria can develop defense mechanisms against antibiotics. For example, some bacteria have developed biochemical “pumps” that can remove an antibiotic before it reaches its target, while others have evolved to produce enzymes to inactivate the antibiotic.
The answer to your question is megakaryocytes.