Bloom syndrome (BS) is a rare autosomal recessive disorder characterized by growth deficiency, immunodeficiency, genomic instability, and the early development of cancers of many types. BLM, the protein encoded by BLM, the gene mutated in BS, is localized in nuclear foci and absent from BS cells. BLM encodes a DNA helicase, and proteins from three missense alleles lack displacement activity. BLM transfected into BS cells reduces the frequency of sister chromatid exchanges and restores BLM in the nucleus. Missense alleles fail to reduce the sister chromatid exchanges in transfected BS cells or restore the normal nuclear pattern. BLM complements a phenotype of a Saccharomyces cerevisiae sgs1 top3 strain, and the missense alleles do not. This work demonstrates the importance of the enzymatic activity of BLM for its function and nuclear localization pattern.
<u><em>What DNA sequence were the researchers trying to detect? </em></u>
<u><em>Are you referring to the choices below?</em></u>
Answer:
C. Shape is the correct answer
Explanation:
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The 3 checkpoints include G1 where the cell growth is checked, G2 where the integrity of the DNA/chromosome is checked, and M where the integrity of the metaphase plate is checked.
<h3>Cell cycle checkpoints</h3>
There are 3 regulatory checkpoints in the life cycle of cells:
- G1: the size of the cell, the presence of growth factors, and the integrity of the DNA are checked before the cell irreversibly commits to division.
- G2: the integrity of the DNA and the correctness of the replication process at the S-phase are checked.
- M: correct attachment of the spindle fibers to the chromosomes at the metaphase plate is checked.
More on cell cycle checkpoints can be found here: brainly.com/question/2128300
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