Temperature can cause an enzymes shape and function to alter due to the fact that once an enzyme reaches its optimum level, if it goes over it begins to denature. If the temperature is below optimum, then an enzyme will work at a slower rate. Also, the pH can affect an enzyme.
Individuals with these mutations typically have familial hypercholesterolemia.
These genes provide information for the formation of the low-density lipoprotein receptor, a receptor that binds to low-density lipoproteins (LDLs). LDLs carry the cholesterol in the blood and regulate the amount of cholesterol in the circulation. Mutations to these genes either reduce the number of receptors or cause several disruptions to their function. This results in high blood cholesterol levels and in a higher risk for heart disease.
Because Thymine is "replaced" with Uracil, the corresponding RNA Code for AAT would be UUA.
