5. In Type 2 diabetes, the connection between insulin signaling and regulation of glycogen synthesis is lost. Select ONE ENZYME
involved in regulation of glycogen metabolism by insulin or glucagon that you think would be a good target for activation or inhibition as a Type 2 diabetes treatment. Explain in five (5) sentences or less: a. Which enzyme you have chosen and why you have chosen it, b. Whether you would aim to activate or inhibit it, and rationale for this choice.
a and b) Metformine inhibits the enzime glycerol-3-phosphate dehydrogenase. This enzime catalyzes the conversion of glycerol phosphate to dihidrocetone phosphate. This decreases the concentration of NAD on the cytosol, and the realation NADH/NAD increases in this comparment, and decreases on the mitochondria, which restricts the conversion of lactate to pyruvate, preventing the use of the substracts to the gluconeogenesis.
