Answer:
Yes
Explanation:
The goal of cancer gene therapy is to introduce new genetic material into target cells without toxicity to non-target tissues.The patient with recurrent or metastastic cancer is often considered incurable. A variety of chemotherapeutic agents has been used alone, and in combination, for the treatment of recurrent oral squamous cell carcinoma. However, chemotherapy is associated with well-known toxicities and has demonstrated no clear impact on survival in patients with recurrent oral cancer. Local and regional disease control is paramount, underscoring an urgent need for more effective therapies. Gene therapy has the potential to target cancer cells while sparing normal tissues. Such a strategy may be useful for recurrent disease as well as in the adjuvant setting (i.e., at the resected tumor margins).
Although gene therapy as a treatment for disease holds great promise, progress in developing effective clinical protocols has been slow. The problem lies in the development of safe and efficient gene-delivery systems. This review will evaluate the problems and the potential solutions in this new field of medicine.
Answer: Paracrine
Explanation:
Paracrine signaling is a form of cell signaling in which a cell produces a signal that induces changes in nearby cells, altering the behavior or differentiation of those cells. Molecules known as paracrine factors diffuse over relatively short distances (local action), unlike endocrine factors (hormones that travel considerable distances over the circulatory system), juxtacrine interactions, and autocrine signaling.
<u>Cells that produce paracrine factors secrete them into their immediate extracellular environment. </u>These factors then travel to nearby cells where the gradient of the factor received determines the outcome. However, the exact distance a paracrine factor can travel is not known with certainty. Paracrine signaling is a form of cell signaling in which a cell produces a signal that induces changes in nearby cells, altering the behavior or differentiation of those cells. <u>Molecules known as paracrine factors diffuse over relatively short distances</u>, unlike endocrine factors (hormones that travel considerable distances over the circulatory system), juxtacrine interactions, and autocrine signaling.
Cells that produce paracrine factors secrete them into their immediate extracellular environment. These factors then travel to nearby cells where the gradient of the factor received determines the outcome. However, the exact distance a paracrine factor can travel is not known with certainty.
In the case of infection, cells of the innate immune system secrete different cytokines into their immediate extracellular environment that attract other immune system cells such as neutrophils and lymphocytes, to fight the infection.
1. All living things are composed of cells
2. Cells are the basic unit of structure and function in living things
3. All cells are produced from other cells
