Oral medication is a system of medicine in which substances that cause symptoms of an illness are ingested by the patient in highly diluted forms means with water or in a liquid solution having less amount of medicine, while on the other hand, topical medication is a system of medicine in which the medicines having healing substance is only used externally and never ingested orally.
Alcohol can affect all of those pertaining to your body system if long overuse of alcohol but mostly I believe it will really affect your digestive system