Insulin plays an important physiologic role, especially in the liver, muscle, and adipose cells, in homeostasis of blood glucose concentration (4). For this reason, the liver, muscle, and fat have been regarded as major target tissues for insulin.
The primary targets for insulin are liver, skeletal muscle, and fat. Insulin has multiple actions in each of these tissues, the net result of which is fuel storage (glycogen or fat). Glucose enters the circulation either from the diet or from synthesis in the liver.
