1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
ludmilkaskok [199]
2 years ago
13

Serpins are naturally occurring proteins that serve as serine protease inhibitors. Serpins bind to the enzyme and are cleaved, b

ut the acyl enzyme intermediate cannot behydrolyzed leading to irreversible inhibition. One of the serpins is a potent inhibitor of the serine protease trypsin and, as expected, contains an arginine at the site of cleavage. Using arrows to show the flow of electrons, draw the mechanism for theinhibition of trypsin by this serpin, labeling all intermediates. Draw the side chains of important enzyme amino acids, and show all hydrogen bonding within the enzyme-substrate complex. Also be sure to include the important arginine on the inhibitor including its side chain.
Biology
1 answer:
Veseljchak [2.6K]2 years ago
3 0

Answer:

Explanation:

The serpins are components of human plasma and its mutations result in numerous genetic diseases, such as caused by the deficiency of α 1 -antitrypsin. They are proteins of high molecular mass (350-500 amino acids) and have been identified in numerous organisms, from viruses to mammals. The serpins interact with the target enzyme by a similar mechanism on a substrate, although an irreversible interaction where the bond occurs serpin adopts different conformations to interact with the protease target, causing a deformation of the active site of the protease.

The mechanism of inhibition of Trypsin by serpin can be seen in the image below.

You might be interested in
Why do we need to breathe? explain​
alex41 [277]
To be like mega mind
5 0
2 years ago
Some careers involve daily exposure to dangerous situations, which can lead to emotional burnout. A person with damage to the am
Juliette [100K]

The limbic system is a region in the brain consisting of the thalamus, the hypothalamus, the hippocampus, and the amygdala.

When a person has amygdala damage, it would be expected to disrupt the integration of fear.

So, this kind of person will be efficient under fear situations avoiding emotional burnout.

Careers like bridge climbing or skydiving instructor are good for this kind of person.

6 0
3 years ago
The higher the temperature of water, the faster an egg will cook.
Furkat [3]

The answer is <u>True</u><u>.</u> When higher is the temperature of water, the faster an egg will cook.

8 0
2 years ago
Read 2 more answers
The Genectic units called ________ are made of sugar, a(n) ________ Group, and a(n) ________ base.
NNADVOKAT [17]

Answer:

A nucleotide consists of a sugar molecule (either ribose in RNA or deoxyribose in DNA) attached to a phosphate group and a nitrogen-containing base. The bases used in DNA are adenine (A), cytosine (C), guanine (G), and thymine (T).

Explanation:

6 0
2 years ago
A pap smear is used to detect abnormal cells in the
coldgirl [10]

Answer:

cervix

Explanation:

abnormal cells lead to cervical cancer, so doctors do pap smears

6 0
2 years ago
Other questions:
  • What human activities prevent the artificial ecosystem of the city park from changing?
    6·2 answers
  • Why is the Great Garbage Patch known as “Trash Vortex”.
    15·1 answer
  • Use the drop-down menus to complete the sentences.
    12·1 answer
  • Is this statement true or false?
    11·2 answers
  • What information must be considered to determine whether a specific molecule will pass through a biological membrane?
    12·2 answers
  • Which nutrient is a cofactor in antioxidant enzyme systems?
    6·1 answer
  • Earth's axis of rotation is almost parallel to the plane of its orbit. Please select the best answer from the choices provided T
    5·2 answers
  • Which characteristic do both viruses and bacteria have in common?
    11·1 answer
  • WILL GIVE 30 POINTS
    7·2 answers
  • How is the information contained in a signaling molecule received by a cell?
    14·2 answers
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!