Can you provide more details ?
The acidic environment of the lysosome and the lysosomal enzymes detach the ligands from their receptors.
Receptor-mediated endocytosis is a process in which cell surface receptors are employed for transporting substances such as proteins, hormones, and metabolites from extra-cellular matrix into the cells. Receptor-mediated endocytosis usually occurs through clathrin (a type of protein)-coated pits and vesicle and it allow only the receptor-specific substances to enter the cell. Under this process, molecule binds to protein receptors after which the receptor molecule moves to clathrin coated pits and vesicle. The cell membrane then folds inwards and there is fusion of a coated vesicle. After this, the ligands are detached from their receptors.
