The nucleolus is the central support structure
For mutations to affect an organism's descendants, they must: 1) occur in cells that produce the next generation, and 2) affect the hereditary material. Ultimately, the interplay between inherited mutations and environmental pressures generates diversity among species.
The term that is being described above is SETTLING POINT. This term has been adopted by some researchers which refers to how our weight thermostats are rather adaptable and are affected by biological factors in the environment. This is based on the setting-point hypothesis.