Higher probability of loss. Chorionic villus sampling (CVS) and Amniocentesis (AC). The prenatal diagnosis technique can be done earlier in fetal development CVS (first trimester --> 10-13 weeks). AC (second trimester --> 16-20 weeks)
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mole=10 x 10⁻³ : 46 g/mol = 2.17 x 10⁻⁴