I would say when the patient is suffering from extreme muscle spasms, anxiety or stress; very possibly pulled muscles or muscle pain as well.
Answer:
The further it falls the slower the reaction time.
Appetite is not linked to hunger since appetite is the activity and drive in order to eat whereas hunger is the physical and mental state in which a person needs to eat.
Also appetite is linked to many unhealthy behaviors that can result to other symptoms of eating disorders which causes deletrious effects on one's mental and biological state.