Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
The correct answer is "temporal lobe".
Explanation:
The temporal lobe is the part of the brain involved in primary auditory perception by receiving sensory information from the ears and secondary areas and translating in into meaningful units such as speech and words. It was proved since 1954 by Mishkin and Pribram that the removal of the temporal lobe part of the brain produces a severe visual discrimination deficit in monkeys. This is the case for Maria's experiment, when the monkey was not able to differentiate between the rectangle and the cylinder anymore. Therefore, it is very likely that the part of the monkey's brain that was removed was the temporal lobe.
Answer:
Increase in eosinophils.
Explanation:
The leukocytes are the white blood cell that plays an important role in the immune system. The white blood cell include eosinophil, basophil, neutrophil and monocytes.
The allergic reactions that are caused by hay fever or asthma is marked by the excess increase in the number of eosinophils in the body. The eosinophils are the first to reach at the site of parasitic infections and protect the body during the allergic reactions.
Thus, the answer is eosinophils.
It cannot survive because an earth worm will not become 2 new worm. The head of the worm may survive and regenerate a tail. But if original tail of the worm may not survive because it will not be able to grow a new head or the rest of its vital organs and it will die. I hope this helps. :)
