Question

Individuals with a mutation in the gene for apolipoprotein B-100 produce very low levels of this protein, which is a component of LDL. How would accumulation of fat in the liver be affected and would this result in hypercholesterolemia or hypercholesterolemia

Answer 1

Answer:

Fats would accumulate in the liver and the individual would show hypocholesterolemia

Explanation:

Familial hypercholesterolemia is a genetic disorder caused by a reduction and/or defect in the low-density lipoprotein (LDL) receptor. Moreover, apolipoprotein B is the unique protein component of LDL, which plays a critical role in lipid metabolism by binding the LDL receptor. Familial defective apolipoprotein B-100 refers to an inherited disorder associated with mutations of the apolipoprotein B-100 that leads to moderate or severe cases of hypercholesterolemia. Mutations in apolipoprotein B-100 are associated with a reduction in the binding capacity of LDL to the LDL receptor, thereby leading to hypercholesterolemia.