Darwin's theory of evolution by natural selection can explain how antibiotics are becoming defective because the bacteria that is trying to be fought off might have had a mutation making it more likely to survive. Once that surviving bacteria makes offspring most of the first generation will die from the antibiotic but soon all of their offspring will produce a resistance to that antibiotic.
E. On the inside of the folded chain, away from water.
As epithelial makes the outer covering of all the organs and skin is also made of epithelial...so to be sure that it does not get depleted or destroyed due to friction and other external cause ...it should be highly generative !
Generally nonsense is much much worse. It creates a premature stop code which can throw off the entire chain of codons and makes things much much worse. A good way to remember this is that the nonsense mutations make the codons not make sense.