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telo118 [61]
2 years ago
15

I need help please?!!!!!

Biology
2 answers:
Damm [24]2 years ago
6 0

Answer:

I think it might be force

Explanation:

I am so sorry if this is wrong

Hunter-Best [27]2 years ago
4 0

Answer:

Force

Explanation:

Force is defined as a push or pull acting on an object. Forces include gravity, friction, and applied force. Force causes changes in the speed or direction of motion. These changes are called acceleration

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Hence, option D is correct

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Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.

Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.

However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.

meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.

We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.

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Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.

Learn more about breast cancer here : brainly.com/question/6747562

#SPJ4

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