Answer:
The correct insulin pathway is described as under:
2. Binding of insulin to the alpha subunit of the insulin receptor
8. Activation of insulin receptor tyrosine kinase
3. Phosphorylation of IRS proteins
6. Phosphorylation of phosphinositide 3-kinase (PI-3K)
4. Conversion of PIP2 to PIP3
7. Activation of PIP3-dependent protein kinase B (PDK1)
5. Glut4 receptors transported to the cell membrane
Explanation:
The insulin signaling pathway is described as under:
RTK (receptor tyrosine kinases) which is a receptor for insulin is an extracellular receptor but in contrast to other cell surface receptors it is catalytic in nature. In the absence of insulin (ligand), it is monomeric but as soon as it gets activated (activation occurs upon ligand binding), it undergo dimerization. It leads to auto-phosphorylation in it's tyrosine residue which subsequently leads to phosphorylation of tyrosine residue of other receptors. Such hyper-phosphorylated receptor have high affinity with enzyme/molecule like IRS protein which have SH2 domain . IRS down stream activates phosphinositide 3-kinase (PI-3K). This enzyme converts component of animal cell membrane PIP2 into PIP3. PIP3 also remains membrane bound but it has the potential to phosphorylate another enzyme named as PIP3-dependent protein kinase B (PDK1). Further, PDK1 leads to the activation of Akt or PK-B. Akt is a serine-threonine kinase which ultimately leads to the recruitment of Glut4 receptors on cell membrane for uptake of more and more glucose into the cell.
Note: Apart from this Akt also phosphorylates another protein named as FOXO which ultimately causes cell growth, Akt can also phosphorylate BAD protein so as to restrict cell apoptosis or we can say it leads to cell survival, Akt also leads to translation in a cell with the help of mTOR raptor etc.
First cousins share a grandparent, second cousins share a great-grandparent.
Answer:
I don't know
Explanation:
wait is this like for an assignment or sum?
Answer:
These bands represent different confirmation of DNA
Explanation:
pGLO DNA is a plasmid DNA that is used as a vector for genetic engineering. Plasmid DNA is found in supercoiled confirmation in vivo. The double helix forms extra twists to easily fit inside the cells. During isolation of plasmid from the cell, nicks can be introduced in the DNA due to harsh isolating methods or contamination by nuclease. As a result the supercoiled confirmation is changed into circular confirmation. It is bulkier than the supercoiled form and travels more slowly. When both DNA stands get cut at the same place, the DNA gets liner confirmation. In the end, supercoiled DNA runs the fastest on gel followed by linear DNA and then the circular DNA.
Answer:
The mechanism is natural selection.
Explanation:
Natural selection is the mechanism that these air-breathing fishes have gone through to survive. This mechanism allows species to survive and reproduce due to differences in the phenotypes of every individual in the specie, throughout the time the heritable traits that every individual inherits changes according to the environment and the characteristics of its ancestors.
