It results in change of the phase temperature and heat
Function of an enzyme is to lower reaction's activation energy and to increase speed of a reaction, but to make it happen, enzyme and substrate must fit spatially. The shape of an enzyme is essential to make enzyme-substrate complex - if active site of an enzyme doesn't fit to substrate, there won't be a enzyme-catalised reaction.
I think its a , but double check because i dont want it to be wrong .
Answer:
It's a deletion, a loss of one or more nucleotides