Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
Learn more about mutations here : brainly.com/question/17031191
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Rounded, Rod-like & Spiral
Anaerobic , they don’t need oxygen so the bacteria will still live and infect the wound
Exaptation
Explanation:
In this example, the lateral extensions that developed were meant for thermoregulation.
But these became sufficiently large to support gliding through the air and later on were used for flight.
Thus the structure assumed a function for which it was not meant and its original function shifted to a completely different dimension giving rise to modern insect wings. So we can say that this is an example of Exaptation.
Answer:
Hey there
1 It will make it loud for them; negitive
2 It will disturb the wildlife and natural processes; negitive
3 It will remove plants in order to insert the road and animals will get hit by cars going on the road; negitive
4 More roads more cars more driving more pollution; negitive
5 It will make it easier for logging companies because they can hall more wood; negitive
6 Sense there is a new road it will be easier for tourist to come; negitive
