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<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
Answer:
An ecological community is made up of all the populations of all the different species that live together in a particular area. The interactions between different species in a community are called interspecific interactions, inter- means "between".
Answer and explanation;
-All lipids contain carbon, hydrogen, and oxygen. Some of them also contain nitrogen and phosphorus. The four main classes of lipids are fats, waxes, sterols, and phospholipids. Fats are triglycerides.
-The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes.
-Lipids are water-insoluble (hydrophobic), and this property is put to great use in the organisation of cells and tissues.
For example; phospholipids are a class of lipids that is amphipathic; that is it contains fatty acid tails that are hydrophobic, and a phosphate head that is hydrophilic. This means the phosphate group will orientate itself towards water and away from the rest of the molecule, and also gives rise to the special properties that allow phospholipids to be used to form membranes.