Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
I = 2.1 A
Explanation:
This is physics, but I will answer here either way.
First, the battery produces a voltage of 12 V in a resistor with 6 ohm, and we want the current flow (I). We need to apply the following expression:
V = R * I (1)
This is the Ohm's law. From here we can solve for I and:
I = V/R (2)
Now, we just need to replace the data and solve for the current:
I = 12.6 / 6
<h2>
I = 2.1 A</h2>
Hope this helps
Answer:
False, I think it has it’s own purpose somehow, it’s made for no reason
Explanation:
Please give me brainliest
Answer:People look at the fossil record and think the early history of many animals is filled with giants, but not for whales. It's only in recent geological times that whales have achieved really large sizes
Answer:
The sodium–potassium pump is found in many cell (plasma) membranes. Powered by ATP, the pump moves sodium and potassium ions in opposite directions, each against its concentration gradient. In a single cycle of the pump, three sodium ions are extruded from and two potassium ions are imported into the cell.
Explanation:
Hope I helped!
