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EleoNora [17]
2 years ago
9

What is a Philadelphia chromosome?

Biology
2 answers:
TiliK225 [7]2 years ago
4 0

Answer:

"Philadelphia chromosome. A piece of chromosome 9 and a piece of chromosome 22 break off and trade places. The BCR-ABL gene is formed on chromosome 22 where the piece of chromosome 9 attaches. The changed chromosome 22 is called the Philadelphia chromosome."

"The Philadelphia chromosome forms when chromosome 9 and chromosome 22 break and exchange portions. This creates an abnormally small chromosome 22 and a new combination of instructions for your cells that can lead to the development of chronic myelogenous leukemia."

"People aren't born with a Philadelphia chromosome. It happens because of a mistake our bodies can make later in life. The mistake is that a piece of chromosome 9 sticks to a piece of chromosome 22. This mistake leads to a very serious blood cancer called "chronic myeloid leukemia," or CML."

"The Philadelphia chromosome is seen in more than 90% of patients with CML but also in 5% or less of children with ALL (20% of adult ALL) and in 2% or less of children with AML. Different isoforms of the fusion gene may be present in ALL. ALL in a child with the Philadelphia chromosome has a much poorer prognosis."

"Currently, the standard of care in the frontline setting for fit patients is TKI in combination with chemotherapy. Age-adjusted chemotherapy or corticosteroids alone have been used with TKIs in elderly patients with comorbidities with modest long-term benefit."

if it helps you brainliest? :)

mezya [45]2 years ago
3 0

Answer:

A piece of chromosome 9 and a piece of chromosome 22 break off and trade places.

Explanation:

The BCR-ABL gene is formed on chromosome 22 where the piece of chromosome 9 attaches. The changed chromosome 22 is called the Philadelphia chromosome.

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<h2>Explanation:</h2>

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___________________________________________________________

<u><em>Hope this helps :)</em></u>

<u><em>Pls brainliest...</em></u>

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