Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Haploid cells are sex cells or gametes.
Answer:
The correct answer is case control study.
Explanation:
A study in which a comparison is made between the patients carrying the disease with the patients not carrying the disease is known as the case-control study. In the mentioned study, the one carrying the disease is termed as cases, and the one that does not possess the disease is termed as controls.
This form of study is generally done to predict the association between the disease and the risk factor. In case-control studies, only observation is done as no attempt is made to change the course of the condition. The prime objective of the study is to predict the exposure of the risk elements for the individuals present in two groups, that is, controls and cases. This form of study is also called case-referent studies or retrospective studies.
Answer:
B. Both cells use the same molecules for energy
Explanation:
The mitochondrion is considered the powerhouse of the cell and it is the only place that makes energy in the cell
Answer:
carbohydrates, proteins, fats, vitamins, and minerals
Explanation:
