Question

the eyeless gene is required for eye formation in drosophila. it encodes a homeodomain. a. what would you predict about the biochemical function of the eyeless protein? b. where would you predict that the eyeless gene is expressed in development? c. the small eye and aniridia genes of mice and humans, respectively, encode proteins with very strong sequence similarity to the fly eyeless protein, and they are named for their effects on eye development. devise one test to examine whether the mouse and human genes are functionally equivalent to the fly eyeless gene.

Answer 1

Briefing:

In Drosophila, the eyeless gene is necessary for the development of eyes. Given that it encodes for a homeodomain, its protein may have a role as a transcription factor that binds DNA in a specific sequence. In situ hybridization can be used to study the gene's mRNA expression pattern, and immunological methods can be used to study the protein.

A. Since the eyeless gene in Drosophila encodes for a homeodomain, one potential use for its protein is as a DNA-binding transcription factor that binds to specific DNA sequences.

B. As implied by its function, the eyeless gene should be expressed in the Drosophila cells in charge of eye formation. In situ hybridization of the gene's mRNA expression is one potential test to find the gene. The protein can also be seen via a variety of immunological and staining methods. It is possible to do gene deletion experiments to see if Drosophila will retain its eyes or go blind. Additionally, genetic engineering can determine whether the eyeless gene expressed in other organs can result in the creation of eyes.

C. Transgenic tests can be used to determine whether the Small eye and Aniridia genes function similarly to the fly eyeless gene. Since both of these function as master switches for the genes that create eyes, it is possible to transfer the mouse Small eye gene into Drosophila to observe whether it is expressed. These, however, are simply Drosophila eyes and not comparable to mouse eyes.

Describe DNA:

All known organisms, including many viruses, require deoxyribonucleic acid, a polymer comprised of two polynucleotide chains that coil around one another to create a double helix, to develop, function, grow, and reproduce. DNA and ribonucleic acid are examples of nucleic acids.

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