Question

A. transient shortage of oxygen (global ischemia) releases excess glutamate into the extracellular fluid of the brain. this causes neuronal death by hyperexcitation to a greater extent in the hippocampus than in the cortex. which reason best explains why the hippocampus is selectively vulnerable during gloabl ischemia?
a. the mag of ap is greater in hippocampal than cortical neurons
b. the expression of NMDA receptors is more abundant in hippocampal than cortical neuorns
c. hippocampal neurons generate a more negative postsynaptic potential than cortical neurons
d. hippocampal synapses have faster neurotransmitter diffusion rates compared to cortical synapses

Answer 1

Answer:

The correct option is B: the expression of NMDA receptors is more abundant in hippocampal than cortical neurons

Explanation:

Global Ischemia is known to cause damage to neurons in distinct areas of the brain. The expression of NMDA, a pattern of selective vulnerability capable of being reproduced is usually seen in the dorsal hippocampal of animals, especially rodents, where the neurons in the CA1 area is mainly affected. Thus, this explains why the hippocampal is the area well faced with a high risk of vulnerability during global ischemia.