A muscle cramp is a sudden, painful contraction of a muscle, during which movement is difficult. At the cellular level during a muscle cramp Myosin and actin filament do not fully detach, so the muscle cannot relax.
Further Explanation:
During the muscle contraction, the calcium activates the channels in the membrane. Potassium is an inhibitor of the calcium. So, as the potassium go out of the cell then eventually leads to decrease level of calcium. This causes the closure of the Na-K channel (negative feedback mechanism). In a hypokalemic condition, the low level of doesn't inhibit the calcium channel. That’s way muscle contraction is not properly done at the cellular level.
In the case of the muscular cramps, the muscle contraction starts with the generation of the action potentials from the brain. The action potential developed the release of the calcium ions movement out of the sarcoplasmic reticulum (storage site of calcium). The calcium released in this process causes the contraction of the myofibrils with the help of the ATP molecules. Meanwhile, the calcium is drive back to the sarcoplasmic reticulum through the fast calcium pumps.
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Answer Details:
Grade: High School
Subject: Health
Topic: Muscle Cramp
Keywords:
Muscle cramp, sarcoplasmic reticulum, calcium, potassium, myofibrils, muscular cramp, activate, cell, hypokalemic condition, cellular level.
