Answer:
There are several reasons for the difference in the blood volume present in males and females.
Few of them are:
Hormones: presence of testosterone in males promotes erythropoiesis. In addition, presence of estrogen in females inhibits erythropoiesis.
Menstrual loss: Females loss few amount of blood every month through menstrual cycle.
Cardiac output can be calculated by multiplying heart rate with stroke volume.
In healthy male at rest, the heart rate is approximately equal to 70beats per minute and stroke volume is approximately equal to 70-80 ml per minute.
Thus, approximately 5000ml or 5 litre of blood is pumped through the heart per minute.