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allochka39001 [22]
3 years ago
11

Which kind of graph would be best for depicting data collected on the weight of a baby every month for six months?

Biology
1 answer:
qaws [65]3 years ago
3 0
For the first question, I would say a line graph. And the one about the human heart, I need some more information.
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Based on the definitions of pharmacophore and privileged structure, outline essential structural features a 1,4-dihyrdopyridine
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Answer:

Explanation:

Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.

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1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.

1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.

A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,

antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .

Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.

2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.

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