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klasskru [66]
2 years ago
13

Explain how tetanospasmin functions to cause disease.

Biology
1 answer:
Strike441 [17]2 years ago
5 0

Answer:

Tetanus Neurotoxin ( TeNT)binds to the presynaptic membrane of the neuromuscular junction is internalized and transported  retroaxonally to the spinal cord.The  spastic paralysis induced by the toxin is due to the blockade of neurotransmitter release from spinal inhibitory interneurons.

Explanation:

The muscular rigidity and spasms of tetanus are caused by tetanus toxin(tetanospasmin) which is produced by  Clostridium tetani, an anaerobic bacillus whose spores survive in soil and cause infection by contaminating wounds.

Tetanus Neurotoxin ( TeNT)binds to the presynaptic membrane of the neuromuscular junction is internalized and transported  retroaxonally to the spinal cord.The  spastic paralysis induced by the toxin is due to the blockade of neurotransmitter release from spinal inhibitory interneurons.

The tetanus shots is a safe and effective way to prevent tetanus and other dangeroud diseases occuring in most cases.

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According to the given information, <em>Candida albicans </em>is a part of the microflora of mouth but becomes pathogenic under certain conditions. In healthy individuals, they do not produce disease as their overgrowth is suppressed by other microbiota and other host resistance mechanisms. The infection occurs only in those individuals with predisposing factors such as weakened immune system or after consumption of antibacterial medications that disturb the normal microbiota and immune competency. This makes it an opportunistic, endogenous pathogen.

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