The best answer to the health and workout question above would be overload. It is evident that the person developed knee pain from running everyday - a sign that the knee was put on a greater amount of stress. This principle of sport training is called the overload and is used to strengthen the ability of that certain muscle to work efficiently.
Maybe a construction worker .. You are building stuff.
The shingles virus is a reactivation of the chicken pox virus.
I think all of the above, i hope that helps! :))