Solution:
It is to apply genomic knowledge effectively in
drug discovery, mechanistic connectivities
between genetic variation and disease
processes need to be established via
systems biology approaches. Humans have
hundreds of functionally specialized cell
types that interact differentially with
environmental factors to influence disease
development and to modulate the effects of
drugs. Metabonomics can provide a means
of modelling these interactions, but the
relationships between ‘endogenous’
metabolic processes and
‘xenobiotic’ metabolism
are poorly understood, especially with
respect to environmental factors. We
present an overview of ‘global’ mammalian
metabolic conversions that should be
accounted for in human systems biology
models and propose a new probabilistic. Approach to help understand gene–disease relationships and vexed
issues of idiosyncratic drug toxicit etc.
Thus this is the required answer.
