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seropon [69]
3 years ago
7

A mutation that results in a single amino acid substitution in Ras abolishes its ability to hydrolyze GTP, even when GTPase-acti

vating proteins (GAPs) are present. Approximately 30% of human cancers have this mutation in Ras. The pharmaceutical company AztraZeneca, which markets popular breast cancer drugs like Iressa® (generic: Gefitinib) has recently developed a new drug that prevents the dimerization of a receptor tyrosine kinase expressed in lung cancer cells, which signals via Ras. Would you expect this new drug to be effective for the treatment of cancers that express the mutant form of Ras?
Biology
1 answer:
Drupady [299]3 years ago
7 0

Answer:

The new drug will not be effective against the treatment of cancer.

Explanation:

The drug will not be effective against the cancer treatment because the drug will inhibit the dimerization of receptor tyrosine kinase (RTK) but as the Ras has undergone mutation due to replacement of one amino acid, it will be constitutively expressed and the drug is not effective in stopping the Ras functioning.

Thus, Gefitinib cannot work against the cancerous cell as it is not potent to stop the functioning of mutant Ras protein.

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If you treated embryos with a Notch inhibitor how would this affect the specification of venous and arterial endothelial cells?
Alisiya [41]

Answer:

d. all endothelial cells would be venous

Explanation:

The Notch signaling pathway is a cell signaling system which consist basically of 4 NOTCH genes ( NOTCH1, NOTCH2, NOTCH3, and NOTCH4) each of them having the information to build a particular cell membrane receptor protein.

It has been demonstrated in zebrafish embryos that Notch signaling are highly determinant factors during vascular development, and a key function of these genes was specifically to regulate the differentiation of arterial fate in endothelial cells.

Notch signaling-deficient embryos showed a loss of expression of arterial markers such as ephrinB2 from arterial vessels with an accompanying expansion of venous markers into normally arterial domains. In contrast, embryos in which Notch signaling had been ectopically activated, meaning an activation out of "proper" place (where not expected, e.g. venous endothelial), exhibited the contrary phenotype, this is a suppression of vein-specific markers with ectopic expression of arterial markers in venous vessels.

To summarize, when Notch is supressed (in this case inhibited with a specific Notch inhibitor) arterial fate of endothelium is not followed, and venous fate is stablished. Thus, endothelial cells (those expected to form venous tissues but also arterial ones) would specified as venous.  

4 0
3 years ago
Muscular exercise presents a dramatic test of the body's homeostatic control systems because it results in large _____.
kicyunya [14]

Muscular exercise presents a dramatic test of the body's homeostatic control systems because it results in large amounts of heat production.

Homeostatic control systems- A body's physiological ability to maintain a steady internal environment in response to changes in the external environment is known as homeostasis.

Heat Production- The term "thermogenesis" refers to the process through which energy is lost by producing heat with specialization.

Energy- In biology, cells frequently store energy in macromolecules, especially lipids and carbohydrates (sugars). When chemical bonds are formed, such as during the redox reactions of cellular aerobic respiration, energy is released.

Redox Reactions- A reaction that happens when an oxidizing material and a reducing substance come into contact.

To know more about the homeostatic control system, click on the below link,

brainly.com/question/3913414

#SPJ4

7 0
2 years ago
Weathering is a _____ force since it naturally breaks rock down into sediment.
svetlana [45]

Answer: C

Explanation:

5 0
3 years ago
How do chromosomes carry information
likoan [24]

Answer:

DNA.

Explanation:

Chromosones use a molecule called DNA to carry genetic information. A DNA exists in a cell's nucleus within structures named chromosones.

Good luck~!

6 0
3 years ago
Read 2 more answers
6 What is a covalent bond? a bond in which electrons are transferred a bond in which electrons are shared a bond in which electr
ki77a [65]

iconic bond -> sharing of many electrons

metallic bond -> sharing of electrons

covalent -> transferring of electrons

hope this helps...

4 0
3 years ago
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