-The two hormones bind to different receptors and use a different second messenger.
Explanation;
-Most hormones circulate in blood, coming into contact with essentially all cells. However, a given hormone usually affects only a limited number of cells, which are called target cells. A target cell responds to a hormone because it bears receptors for the hormone.
-Insulin and glucagon are hormones secreted by islet cells within the pancreas. They are both secreted in response to blood sugar levels, but in opposite fashion.
In this scenario, once in a target tissue, the water soluble hormones which is the answer would then bind to the intracellular receptors inside the cell membrane. Hope this is the right answer and would be of big help then.
