Answer:
Binding affinity measures the strength of the interaction between a molecule to its ligand; it is expressed in terms of the equilibrium dissociation constant; and the higher value of this constant, the more weaker the binding between the molecule and the ligand is. On the other hand, small constans means that the interaction is tight. So "C" binds most tightly to the enzyme and "D" binds least tightly.
The nuclear reactions which are under experimenter's control are said to be controlled nuclear reactions. In this, you can maintain the speed of the incident particle. α and β-decay process are examples of non-controlled nuclear reactions.
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