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Verdich [7]
3 years ago
9

The side chain of histidine has a typical pKa value in the range of 6.5-7.4. However, when analyzing the pKa values in a particu

lar protein, scientists determined that one particular His residue has an unusually low pKa value of 4.8. Which of the following statements correctly explain this anomaly?
1) The microenvironment around a residue can impact its pKa value.
2) A positively charged amino acid must be in close proximity to this residue.
3) A negatively charged amino acid must be in close proximity to this residue.

Statements 1 and 2 are correct.
Statements 1 and 4 are correct.
Statements 1, 2, and 4 are correct.
Statements 2, 3, and 4 are correct.

4) This residue must be located on the surface of the protein.
Chemistry
1 answer:
Leona [35]3 years ago
8 0

Answer:

Statements 1 and 2 are correct.

Explanation:

The microenvironment around a amino acid residue can impact its pKa value according with the Born effect. If there is a positively charged environment, like in the second option, the pKa value will decrease, just as it happens in the histidine residue. So the correct answers are 1 and 2.

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Explanation:

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As equation for ideal gas is as follows.

PV = nRT

And, at constant temperature the pressure is inversely proportional to volume which also means that number of moles are also constant in Boyle's law.

Thus, we can conclude that temperature and number of moles are the conditions which remain constant in Boyle's law.

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Answer:

Following are the answer to this question:

Explanation:

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please find the attachment:

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3 years ago
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