Question

An increase in the ratio of insulin to glucagon will increase the activity of which of the following enzymes (+ indicates activity is increased; - indicates activity is not increased by insulin)?

Answer 1

Answer: An increase in the ratio of insulin to glucagon will increase the activity of --

- Acetyl-CoA carboxylase(+)

-Phosphofructokinase PFK2(+)

-Glycogen synthase(+)

- Hormone sensitive lipase (-). The hormone sensitive lipase activity is not increased with increased insulin activity.

Explanation: increased insulin - glucagon ratio is usually high in fed state.Insulin helps the cells absorb glucose, reducing blood sugar and providing the cells with glucose for energy. When blood sugar levels are too low, the pancreas releases glucagon. Glucagon instructs the liver to release stored glucose, which causes blood sugar to rise.