Garrod hypothesized that "inborn errors of metabolism" such as alkaptonuria occur because...genes dictate the production of specific enzymes, and affected individuals have genetic defects that cause them to lack certain enzymes.
Explanation:
Archibald Garrod researched on alkaptonuria and proposed the ‘one gene-one enzyme’ hypothesis. This led to the finding that alkaptonuria is caused due to an inherited or “inborn error of metabolism”.
This hypothesis stated that each gene codes and responsible for a single specific enzyme which facilitates a particular step in the metabolic processes.
According to Garrod, a mutation of a particular gene leads to specific error or defect leading to a lack of a particular enzyme that takes part in the biochemical metabolic pathways. This disrupts the metabolic pathway at the specific enzymatic action point.
In alkaptonuria, it was found that the defective phenotype of dark urine is due to the inborn error happening during the waste elimination process.
Anna should have an amniocentesis, also called amniotic fluid test or (AFT). This will show if there are any infection, genetic disorders or chromosome abnormalities.
B TODDLER hood this helps
Explanation:
Isotonic contractions generate force by changing the length of the muscle and can be concentric contractions or eccentric contractions. A concentric contraction causes muscles to shorten, thereby generating force. Eccentric contractions cause muscles to elongate in response to a greater opposing force.
