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The puppies heads are often to big to fit through their mothers birth canal. They may get birth defects like flat chests, if their face are wrinkly they get acne and eye problems, and they are prone to skeletal disorders like hip dysplasia.
Waste would start to build up in the cell since lysosomes have the role of intracellular digestion of waste materials.
A known disease that is caused by a lysosomal malfunction is Hunter's disease
Medulla oblongata is the part of the brainstem that controls the autonomic functions such as sneezing, coughing, digestion and etc.
