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Brilliant_brown [7]
3 years ago
14

What are the respective roles of grb2 and sos in the activation of ras by egfr?

Chemistry
1 answer:
valina [46]3 years ago
5 0

Answer:

Role is defined below

Explanation:

A small GTP-binding protein, is an important module of the signal transduction pathway used by growth factors to initiate cell growth and differentiation. Cellular activation with growth factors such as epidermal growth factor (EGF) induces Ras to move from an inactive state linked to GDP to an active state linked to GTP. In recent times, a mixture of genetic and biochemical studies has resulted in the elucidation of a signaling pathway that leads from growth factor receptors to Ras. After joining EGF, the EGF receptor tyrosine kinase is activated, which leads to receptor auto phosphorylation in multiple tyrosine residues. Signaling proteins with homology domains Src 2 (SH2) then bind to these phosphorylated residues in tyrosine, initiating multiple signaling cascades. Distinct of these SH2 area proteins, Grb2, exists in the cytoplasm in a preformed complex with a second protein, Son of Sevenless (Sos), which can catalyze the Ras GTP / GDP exchange. After stimulation of the growth factor, the phosphorylated EGF receptor with tyrosine binds to the Grb2 / Sos complex and translocates it to the plasma membrane. It is believed that this translocation brings Sos closer to Ras, which leads to the activation of Ras. In dissimilarity, the insulin receptor does not bind Grb2 directly, but rather induces the tyrosine phosphorylation of two proteins, the substrate-1 insulin receptor and Shc, which bind to the Grb2 / Sos complex. Once Ras is activated, a cascade of protein kinases that are important in a myriad of growth factor responses is stimulated.

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A scientist needs to collect a 0.050 mole sample of helium, but needs to know how large his helium container should be. What vol
Mumz [18]

We can use the ideal gas equation:

PV = nRT

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We will have to convert from Pa to atm or viceversa.

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8 0
3 years ago
Label each of the following changes as a physical change or chemical change. Give evidence to support your answer.
SVEN [57.7K]

Answer:

A catalytic converter changes nitrogen dioxide to nitrogen gas and oxygen gas is a chemical change.

Explanation:

Hello.

In this case, since physical changes do not modify the molecular composition and structure of the material undergoing it whereas the chemical change does, for catalytic converters we should know they promote chemical reaction in which the composition is changed; for instance, for the given example, the following chemical reaction is the evidence:

2NO_2\rightarrow N_2+O_2

As you can see, nitrogen and oxygen are no longer bonded but separated by themselves, therefore, this is a chemical change.

Best regards.

3 0
3 years ago
At a certain temperature, the solubility of strontium arsenate, Sr3(AsO4)2, is 0.0540 g/L. What is the Ksp of this salt at this
blondinia [14]
 <span>Get into moles first. .0590 grams over 540.8 grams per mole = 1.09 x l0^-4 moles 

Sr3(As04)2 = 3 Sr++(aq) plus 2 As04^-3(aq) 

Ksp = (Sr++)^3(As04^-3)^2 

(Sr++) = 3 X l.09 x l0^-4 = 3.27 x l0^-4 

(As04^-3) = 2 x l.09 x l0^-4 = 2.18 x l0^-4 

<span>Ksp = (3.27 x l0^-4)^3 (2.18 x l0^-4)^2 which equals 1.66 x 10^-18th


I hope my answer has come to your help. Thank you for posting your question here in Brainly.</span></span>
7 0
3 years ago
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