Answer:
Drug tolerance occurs when a drug has been consumed continuously, producing a reduction in its effects on the body. In this way, it is necessary to increase the dose of the substance to feel its effects again.
Not all substances produced tolerance; dependence on the chemical composition of drugs and the brain's ability to differentiate them from their own neurotransmitters. For example, they can cause tolerance to alcohol, illegal drugs, drugs such as benzodiazepines or substances such as caffeine.
Tolerance is part of a compensatory mechanism that the brain develops. When the drug begins to exert its effects on the body, the brain detects the existence of an alteration in its balance or homeostasis.
The main response of the brain to this threat to its normal functioning is to resist. To do this, adapt the receivers and mobile devices to the drug so that it does not take effect.
In short, brain receptors become insensitive to the addictive substance. Thus, the person needs to consume a higher dose to feel its new effects.
If the person has used drugs regularly enough to experience tolerance, they will suffer withdrawal symptoms when they stop taking the substance.
